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The menopause can be tough – managing weight gain, dealing with hormone fluctuations, and other physical changes can all take their toll. The good news is that there are medications that can help make the process less difficult.
Mounjaro (active ingredient tirzepatide) is a new-generation weight loss drug that has become popular for those struggling with obesity or type 2 diabetes.
But what about Mounjaro for menopause? Can it help manage symptoms or weight gain during this stage of life – and is it safe to take alongside hormone replacement therapy (HRT)?
Let’s find out. Read on to find out how Mounjaro works, whether it’s suitable during menopause, and what precautions you should be aware of.
Menopause is the stage of a woman’s life that marks the end of her reproductive years – when menstrual cycles end.
Most women go through this stage between the ages of 45 and 55, triggered by a steep decline in oestrogen and progesterone levels (however, there are, of course, exceptions to this).
Some common symptoms of menopause include:
But why do women experience weight gain during menopause?
The hormonal shifts associated with menopause can significantly affect metabolism, which makes weight gain more likely – even without changes to diet or exercise. That’s why many women seek support for managing menopause-related weight changes.
Mounjaro is the brand name for tirzepatide, a dual GIP and GLP-1 receptor agonist. It works by mimicking two gut hormones that help to regulate appetite and blood sugar levels.
These combined effects lead to:
Originally approved for type 2 diabetes, Mounjaro is now widely used to promote weight loss – and clinical research suggests it may be especially effective in women.
On average, female participants lost around 24% of their body weight, compared to approximately 18% in male participants.
Yes, many women take Mounjaro during perimenopause or postmenopause as it can help manage the weight gained as a result of hormonal changes.
However, before taking Mounjaro, always speak with a healthcare provider. At Dr Frank’s, we can determine whether Mounjaro is the right choice for you based on your goals and your medical history.
Note that Mounjaro is not specifically licensed to treat menopause or its symptoms – it’s a weight management tool.
That said, because it helps to reduce body weight and improve insulin sensitivity, it may indirectly support better overall health during menopause.
Although Mounjaro can be beneficial for weight loss during menopause, there are some precautions to bear in mind…
Mounjaro can cause some unpleasant side effects – especially in the first few weeks of treatment. Some common side effects of Mounjaro may include:
Learn all about the side effects of weight loss medications in this helpful blog post.
If you are already experiencing hormonal changes that affect digestion or appetite, these side effects may feel more intense. If you’re struggling with existing menopausal symptoms, we recommend that you discuss potential side effect management strategies with a healthcare professional before starting.
Although rare, and not an officially recognised side effect, some women report spotting and bleeding whilst taking GLP-1 medications – particularly women who have gone through menopause.
This can be distressing, especially if you haven’t had a period in a long time. The exact cause isn’t fully understood, but some potential explanations include:
Mounjaro is not recommended for use during pregnancy, if you're planning to conceive, or if you are currently breastfeeding. If you’re perimenopausal and still have the potential to become pregnant, it’s important to use reliable non-oral contraception while taking Mounjaro.
Tirzepatide may harm an unborn baby, and its effects during pregnancy have not been fully studied.
Mounjaro
£220.00
£120.00/month
Currently, there’s no evidence to suggest Mounjaro interferes with the effectiveness of hormone replacement therapy (HRT).
However, Mounjaro slows down gastric emptying. This may affect how your body absorbs oral medications, including oral hormone replacement therapy (HRT). When HRT isn’t absorbed properly, it may lead to unbalanced hormone levels, potentially leading to breakthrough bleeding.
We explore this in more detail in this blog post: Does Mounjaro cause bleeding after menopause?
HRT and Mounjaro can also both impact metabolism, fluid retention, and appetite, so it’s important to monitor how your body responds when combining the two. Some women on HRT may be more sensitive to side effects like nausea or headaches when they begin Mounjaro – so be sure to liaise with a medical professional (such as ourselves here at Dr Frank’s Weight Loss Clinic) when taking the two medications.
Women also appear to lose more weight on GLP1 medications when taking HRT – In a 2024 study, women using weight loss medications alongside HRT lost 16% of their body weight after one year. Women who were not on HRT lost just 12%.
The British Menopause Society suggests reviewing oral HRT regimens carefully in patients using Mounjaro. This may involve switching to HRT patches or gels, which will not be affected by Mounjaro’s action in the gut.
Weight gain during menopause is common, with more than half of women experiencing weight gain during menopause.
Weight gain during menopause is often caused by:
The good news is that although weight gain is common, it doesn’t have to be inevitable. Here are some ways you can prevent, manage or reduce weight gain during menopause:
Yes, Mounjaro can be extremely helpful in managing weight gain during and after menopause. It can help to counteract the metabolic slowdown and increased fat storage that many women experience during menopause.
A UK clinical trial in 2023 found that women using Mounjaro alongside tailored lifestyle changes lost 12–15% of their body weight over 72 weeks, with an average waist circumference reduction of 8 cm. Participants also experienced an 18% improvement in glucose regulation after six months.
Patients can lose up to 26.6% of their body weight through Mounjaro. This averages around 60lbs in two years.
Although Mounjaro can be very effective in managing weight gain and promoting weight loss, there is currently no research showing that Mounjaro directly alters menopause symptoms like hot flashes or mood changes.
You can purchase Mounjaro in the UK through private weight loss clinics and online providers. You can also get Mounjaro through the NHS, but with strict eligibility criteria.
If you’re struggling with weight gain during menopause and are considering Mounjaro, we’re here to help.
At Dr Frank’s, we offer personalised treatment plans based on your health profile and goals, with licensed clinicians and ongoing support throughout your journey.
Explore our Mounjaro treatment packages or speak to our team to find out if Mounjaro is right for you.
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Lauren lost 5 Stone in just 8 months
“I would advise anyone considering this programme that it's a transformative experience. It has allowed me to embrace life and fully enjoy my twenties.”
Susan lost 5 Stone in just 12 months
“For the first time, losing weight has been both easy and successful in my life.”
Cadi lost 3 Stone in just 12 months
“If you're aiming to lose weight or manage polycystic ovaries, go for this program. It's undoubtedly the best decision.”
Ethan lost 5 Stone in just 5 months
“I’ve never felt so comfortable in my own skin. It's a newfound sense of confidence and well-being that has positively impacted every aspect of my life.”
Dimitra lost 4 Stone in just 8 months
“I cannot recommend this programme enough; it truly works! It's the sole solution that has been effective after my long struggle.”
Lauren lost 5 Stone in just 8 months
“I would advise anyone considering this programme that it's a transformative experience. It has allowed me to embrace life and fully enjoy my twenties.”
Susan lost 5 Stone in just 12 months
“For the first time, losing weight has been both easy and successful in my life.”
Cadi lost 3 Stone in just 12 months
“If you're aiming to lose weight or manage polycystic ovaries, go for this program. It's undoubtedly the best decision.”
Ethan lost 5 Stone in just 5 months
“I’ve never felt so comfortable in my own skin. It's a newfound sense of confidence and well-being that has positively impacted every aspect of my life.”
Dimitra lost 4 Stone in just 8 months
“I cannot recommend this programme enough; it truly works! It's the sole solution that has been effective after my long struggle.”
Lauren lost 5 Stone in just 8 months
“I would advise anyone considering this programme that it's a transformative experience. It has allowed me to embrace life and fully enjoy my twenties.”
