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Mounjaro (tirzepatide) is a popular weight loss and type 2 diabetes medication, and has recently gained attention for its potential benefits in managing menopausal symptoms – specifically weight gain.
Close to 70% of women reported gaining weight during menopause, with weight gain continuing post menopause.
Mounjaro can help – but as more women start taking it, more people are wondering whether Mounjaro can cause bleeding during or after menopause.
Postmenopausal bleeding is not a listed side effect in clinical trials, but some users do report a potential link, especially in those using HRT. But what's really going on? Let's find out.
Read on to find out how Mounjaro might interact with HRT, what to do if you notice bleeding, and when it’s time to speak to a doctor.
Yes, many women take HRT and Mounjaro together without any issues. However, you should make sure you monitor how your body responds, especially during the first few weeks of treatment.
Mounjaro mimics the GLP-1 and GIP hormones, slowing down digestion, regulating blood sugar, and reducing appetite. This, however, can also affect how your body absorbs oral medications such as HRT.
If you are taking HRT, this could lead to fluctuations in hormone levels, potentially leading to spotting or unexpected bleeding.
If you’re concerned, speak to your GP or menopause specialist or one of the Dr Frank’s team. They may suggest that you adjust your HRT dose or switch to a transdermal patch instead.
Mounjaro delays gastric emptying, so it can affect how your body absorbs oral medications – including HRT (Hormone replacement therapy).
If your HRT doesn't get absorbed properly, then your hormone levels may become unbalanced. If you still have a uterus, this can cause breakthrough bleeding.
Please note that this has not been confirmed in formal studies as of July 2025.
If you’re using oral HRT and have noticed bleeding or changes in your symptoms since starting Mounjaro, it may be worth discussing a switch to transdermal HRT (patches, gels, or sprays) with your doctor. These options completely bypass your digestive system, so are less likely to be affected by Mounjaro.
In short, yes – Mounjaro may indirectly cause vaginal spotting in patients taking HRT. Although this is not mentioned in clinical trials or studies, some patients have reported this as a side effect of Mounjaro.
Some potential causes of this include:
You should look into all unexpected vaginal bleeding, regardless of whether you are taking Mounjaro or not. Always speak with your healthcare provider if you experience vaginal bleeding, to rule out anything serious.
Like any medication, Mounjaro can cause side effects. The most common include:
Some people also notice side effects such as sulphur burps. You can learn how to manage sulphur burps here.
Some less common but more serious side effects may include pancreatitis, gallbladder issues, or thyroid-related changes. If anything feels unusual, always report symptoms to your doctor.
Slowly increasing your dose over several months can help minimise these side effects. See our helpful blog on when to increase your Mounjaro dose for more information – or speak with our experts, who will be happy to guide you through the Mounjaro dosing schedule.
Mounjaro
£220.00
£120.00/month
There is currently no formal evidence currently suggesting a dangerous interaction between Mounjaro and HRT. However, the BMS (British Menopause Society) does recommend that if you are postmenopausal, you should monitor any symptoms closely.
If you are taking Mounjaro, you should take oral HRT with caution – or have your routine reviewed by a specialist.
It’s best to avoid oral HRT and opt for a non-oral option instead, as these are generally not affected by Mounjaro.
If you take oral HRT, be sure to speak with your healthcare provider to review your regimen and consider switching to a non-oral option or adjusting your dose.
Many patients prefer to switch to a Mirena coil, which releases progesterone when needed and provides consistent protection.
*Do not stop taking HRT without medical advice.
If you experience any vaginal bleeding after menopause, you should contact your doctor. See your doctor if:
Your GP may recommend a pelvic ultrasound, blood tests, or a referral to a gynaecologist to rule out more serious causes.
Considering Mounjaro to support your weight loss or manage symptoms during menopause? We’re here to help.
At Dr Frank’s, we offer a safe, clinical approach to Mounjaro treatment for Menopause as well as guidance throughout your weight loss journey.
Get started on a Mounjaro Plan today.
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Lauren lost 5 Stone in just 8 months
“I would advise anyone considering this programme that it's a transformative experience. It has allowed me to embrace life and fully enjoy my twenties.”
Susan lost 5 Stone in just 12 months
“For the first time, losing weight has been both easy and successful in my life.”
Cadi lost 3 Stone in just 12 months
“If you're aiming to lose weight or manage polycystic ovaries, go for this program. It's undoubtedly the best decision.”
Ethan lost 5 Stone in just 5 months
“I’ve never felt so comfortable in my own skin. It's a newfound sense of confidence and well-being that has positively impacted every aspect of my life.”
Dimitra lost 4 Stone in just 8 months
“I cannot recommend this programme enough; it truly works! It's the sole solution that has been effective after my long struggle.”
Lauren lost 5 Stone in just 8 months
“I would advise anyone considering this programme that it's a transformative experience. It has allowed me to embrace life and fully enjoy my twenties.”
Susan lost 5 Stone in just 12 months
“For the first time, losing weight has been both easy and successful in my life.”
Cadi lost 3 Stone in just 12 months
“If you're aiming to lose weight or manage polycystic ovaries, go for this program. It's undoubtedly the best decision.”
Ethan lost 5 Stone in just 5 months
“I’ve never felt so comfortable in my own skin. It's a newfound sense of confidence and well-being that has positively impacted every aspect of my life.”
Dimitra lost 4 Stone in just 8 months
“I cannot recommend this programme enough; it truly works! It's the sole solution that has been effective after my long struggle.”
Lauren lost 5 Stone in just 8 months
“I would advise anyone considering this programme that it's a transformative experience. It has allowed me to embrace life and fully enjoy my twenties.”
