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Wegovy Side Effects: What to Expect

Professor Franklin Joseph
Professor Joseph, an expert in diabetes and obesity management, leads clinical trials, chairs the Western Cheshire Diabetes Network, and priorities person-centered care for optimal outcomes.

Thinking of taking Wegovy for weight loss? You probably want to know what some of the common side effects are. 

We’ve got you covered – in today's blog post, we will look into some of the potential Wegovy side effects and ways that you can manage them.

Overview:

  • Most side effects are mild and temporary, especially gastrointestinal ones like nausea or diarrhoea
  • Side effects typically start within the first few weeks of treatment
  • Staying hydrated, eating bland foods, and adjusting your dosage under professional guidance can ease symptoms
  • Rare but serious side effects include pancreatitis and gallbladder issues
  • Alcohol can worsen side effects, especially nausea or low blood sugar

What is Wegovy? 

Wegovy is a prescription-only injectable medication that contains semaglutide. It is designed to help with long-term weight management. It mimics a hormone called GLP-1, which affects your brain’s appetite regulation and helps reduce hunger and calorie intake. 

It’s typically prescribed for adults with a BMI of 30+ (or 27+ with weight-related conditions) and is taken once weekly via injection.

How Does Wegovy Work? 

As a GLP-1 receptor agonist, Wegovy activates GLP-1 receptors in the brain to:

  • Increase feelings of fullness
  • Reduce appetite
  • Slow gastric emptying
  • Lower cravings and emotional eating triggers

When Do Side Effects Start?

Most people experience side effects within the first few weeks of starting Wegovy, especially as the dose gradually increases. 

Your body usually adjusts after a few weeks, but if symptoms persist or become severe, speak to a specialist. Learn what happens during the first week of Wegovy here

Common Side Effects

All medications come with side effects, some of the potential side effects commonly experienced with Wegovy include:

  • Nausea
  • Vomiting
  • Diarrhoea
  • Constipation
  • Headache
  • Fatigue
  • Bloating or gas
  • Mild injection site reactions (itching, redness)

Usually, these symptoms aren't too severe and are mild. They should also begin to disappear over time as your body adjusts to the medication.

However, if symptoms persist and start to affect your day-to-day life, we recommend that you speak to one of our specialist nurses so that they can guide you in the right direction.

Tip – For further details and a more in-depth understanding, read the summary of product characteristics.

Less Common Side Effects

Some people may experience the following side effects, although they are less common:

  • Dizziness
  • Indigestion
  • Belching
  • Acid reflux or heartburn
  • Low blood sugar (especially if taken with diabetes meds)

Rare but Serious Side Effects 

Wegovy is considered a safe and effective medication. However, there is a small risk of serious side effects such as:

  • Pancreatitis including severe stomach pain and vomiting
  • Gallbladder issues
  • Thyroid C-cell tumours (in animal studies but not proven in humans)
  • Kidney problems from dehydration
  • Allergic reactions



Seek medical attention immediately if you experience any of the above.

Mounjaro

GIP & GLP-1 Medication

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Mounjaro

GIP & GLP-1 Medication

Prices start from:

£205.00

£110.00/month

£76 off when you sign-up to our newsletter
Free Shipping
Lose up to 15% in the first year
Cancel anytime
Dose escalation available
Start Assessment

 Are There Any Long-Term Side Effects of Wegovy? 

As mentioned, Wegovy is considered safe when monitored. However, using Wegovy for long periods of time can increase the risk of certain illnesses, such as: 

  • Gallstones
  • Kidney issues (usually due to dehydration)
  • Nutritional deficiencies if not eating enough

This is why regular monitoring is so important. We offer monthly check-ins when you opt for Wegovy at Dr Frank’s Weight Loss Clinic, not only to ensure you are getting the best results possible but to ensure you are taking the medication safely. 

Can Wegovy Affect Mental Health?

Some people do report changes in mood when taking Wegovy - and some patients also report increased feelings of depression and anxiety, although this is rare. These feelings may be linked to changes in appetite, hormonal fluctuations, or rapid weight loss. 

The official patient leaflet for Wegovy does list depression and suicidal thoughts as possible side effects.

 If you do experience changes in your mood, speak to your healthcare provider. 

Can I Drink Alcohol Whilst Taking Wegovy?

Yes, you can drink alcohol whilst taking Wegovy. However, although alcohol isn’t strictly off-limits, it can worsen some side effects. Drinking alcohol may increase the risk of – or worsen – nausea, dizziness, and low blood sugar. 

We recommend that you:

  • Avoid alcohol in the first few weeks
  • Drink in moderation, if at all
  • Don’t drink on an empty stomach

Want to know if you can drink alcohol whilst taking Mounjaro? Find out here. 

How Can I Manage Wegovy Side Effects?

Finding what works for you when managing your symptoms can help your weight loss journey feel more comfortable. Some ways you can manage each symptom include:

Nausea

If you feel nauseous from your medication, stick to eating bland and low-fat foods such as rice, soups and low-fat yoghurts. Keep your portion sizes small at the beginning of your journey. 

Staying hydrated and getting plenty of fresh air can also help to ease nausea. Some people also find that sugar-free mints help to take the edge off.

Diarrhoea

If you are suffering from diarrhoea, you should eat easily digestible foods that are gentle on the digestive system. We recommend that you avoid foods or beverages that contain caffeine as caffeine is a natural laxative, and can worsen diarrhoea. 

Constipation

Eat high-fibre-rich foods and be sure to stay hydrated if you are suffering from constipation. 

Headache

Relaxing in a dark room and lying down, as well as over-the-counter pain medicine can help your headaches subside. It’s also important that you stay hydrated, usually at least 2 to 3 litres and get plenty of fresh air to relieve your headache and prevent it from worsening. 

Injection Site Reactions

If you find that your injection site is red and itchy, you may want to try and numb the area before and after injection, with an ice pack or numbing cream. 

If you find that your injection site is hot or tender to touch and it is producing unusual liquids then you should seek medical attention as it may be infected. If you believe you are experiencing an allergic reaction, seek medical attention. 

Begin Your Wegovy Journey Today

Here at Dr Frank’s Weight Loss Clinic, we offer Wegovy weight loss pens that have been proven as a safe and effective way to lose weight for good so you can live a healthy and balanced life.

We have a team of specialist weight loss nurses who are here to help you every step of the way during your weight loss process and give you guidance and support throughout your journey.

Our Wegovy weight loss pens can help you lose up to 15% of your weight in the first year!

Fill out our online assessment and take the first step towards lasting weight loss today.

Continue Your Weight Loss Discovery

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Lauren lost 5 Stone in just 8 months

“I would advise anyone considering this programme that it's a transformative experience. It has allowed me to embrace life and fully enjoy my twenties.”

Susan lost 5 Stone in just 12 months

“For the first time, losing weight has been both easy and successful in my life.”

Cadi lost 3 Stone in just 12 months

“If you're aiming to lose weight or manage polycystic ovaries, go for this program. It's undoubtedly the best decision.”

Ethan lost 5 Stone in just 5 months

“I’ve never felt so comfortable in my own skin. It's a newfound sense of confidence and well-being that has positively impacted every aspect of my life.”

Dimitra lost 4 Stone in just 8 months

“I cannot recommend this programme enough; it truly works! It's the sole solution that has been effective after my long struggle.”

Lauren lost 5 Stone in just 8 months

“I would advise anyone considering this programme that it's a transformative experience. It has allowed me to embrace life and fully enjoy my twenties.”

Susan lost 5 Stone in just 12 months

“For the first time, losing weight has been both easy and successful in my life.”

Cadi lost 3 Stone in just 12 months

“If you're aiming to lose weight or manage polycystic ovaries, go for this program. It's undoubtedly the best decision.”

Ethan lost 5 Stone in just 5 months

“I’ve never felt so comfortable in my own skin. It's a newfound sense of confidence and well-being that has positively impacted every aspect of my life.”

Dimitra lost 4 Stone in just 8 months

“I cannot recommend this programme enough; it truly works! It's the sole solution that has been effective after my long struggle.”

Lauren lost 5 Stone in just 8 months

“I would advise anyone considering this programme that it's a transformative experience. It has allowed me to embrace life and fully enjoy my twenties.”