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If you're managing type 2 diabetes, you may have heard that some medications can also support weight loss. But is this true? And how does it work?
In short, yes - some diabetes medications can support weight loss. For many, the potential for weight loss is the main reason why they choose certain medications.
In this guide, we explore which diabetes medications are linked to weight loss, why this happens, how long it takes, and what to know if you're worried about weight gain instead.
Yes, certain diabetes medications can lead to weight loss as a side effect. In fact, in some cases, this is an intended part of the treatment.
Weight loss can improve blood sugar levels and insulin sensitivity, which is why medications like GLP-1 receptor agonists (e.g., Ozempic and Mounjaro) have seen a huge surge in popularity recently in those with type 2 diabetes and obesity.
GLP-1 receptor agonists work in various ways, helping to:
This, in turn, can help you to lose weight whilst also improving blood sugar levels.
Here is a breakdown of the main diabetes drug classes and branded medications linked to weight loss:
GLP-1 receptor agonists are a newer class of type 2 diabetes medications that mimic a naturally occurring hormone called GLP-1 (glucagon-like peptide-1). This hormone is released in the gut in response to food and helps to regulate blood sugar levels, slow digestion, reduce appetite, and make you feel fuller for longer.
GLP-1 receptor agonists are known to cause significant weight loss in patients with and without type 2 diabetes.
Some types of GLP-1 receptor agonists include:
➤ Learn more – can semaglutide cause diabetes?
➤ Learn more – can semaglutide reverse diabetes?
➤ Learn more – can Mounjaro cause diabetes?
GLP-1 receptor agonists are some of the most effective diabetes medications for weight loss, especially when combined with lifestyle changes. You typically take these once a day or once a week.
We can determine the best weight loss treatment for you based on your health history and goals – complete a simple assessment today to get started!
SGLT2 inhibitors, also called gliflozins, work by blocking a protein in the kidneys known as sodium-glucose co-transporter 2 (SGLT2), which normally reabsorbs most of the glucose filtered through the kidneys. This helps the body remove excess glucose through urine, lowering blood sugar levels without relying on insulin.
Although effective for diabetes management, these medications don't usually lead to as much weight loss as GLP-1 drugs.
Examples include:
This is one of the oldest and most prescribed diabetes drug classes. Biguanides help to reduce glucose production in the liver and improve insulin sensitivity.
Metformin (sold under the brand name Glucophage) is the most prescribed medication for type 2 diabetes. It is associated with mild weight loss or weight neutrality, making it a good choice if you have type 2 diabetes and you're concerned about weight gain.
Mounjaro
£220.00
£120.00/month
Yes, not all diabetes medications lead to weight loss. In fact, some treatments are associated with weight gain, especially older drugs or those that work by increasing insulin levels in the body.
Some diabetes medications that may lead to weight gain include:
Certain diabetes medications stimulate the body to produce more insulin or supply insulin directly. Although insulin is essential for controlling blood sugar, it also promotes the storage of glucose in fat cells. This can lead to:
Some diabetes medications may also cause water retention or low blood sugar (hypoglycaemia). This may trigger overeating and contribute further to weight gain.
Weight loss results can vary – however, many people begin noticing weight loss after just a few weeks of taking GLP-1 medications such as Mounjaro and Wegovy.
When taking Wegovy, for example, you may begin to notice significant weight loss by month 3. Participants in a clinical trial lost between 5-10% of their starting weight by month 3. Learn more about the Wegovy weight loss timeline here.
On average:
Looking to explore weight loss solutions with expert guidance? Book a consultation with Dr Frank’s Weight Loss Clinic today.
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Dimitra lost 4 Stone in just 8 months
“I cannot recommend this programme enough; it truly works! It's the sole solution that has been effective after my long struggle.”
Lauren lost 5 Stone in just 8 months
“I would advise anyone considering this programme that it's a transformative experience. It has allowed me to embrace life and fully enjoy my twenties.”
Susan lost 5 Stone in just 12 months
“For the first time, losing weight has been both easy and successful in my life.”
Cadi lost 3 Stone in just 12 months
“If you're aiming to lose weight or manage polycystic ovaries, go for this program. It's undoubtedly the best decision.”
Ethan lost 5 Stone in just 5 months
“I’ve never felt so comfortable in my own skin. It's a newfound sense of confidence and well-being that has positively impacted every aspect of my life.”
Dimitra lost 4 Stone in just 8 months
“I cannot recommend this programme enough; it truly works! It's the sole solution that has been effective after my long struggle.”
Lauren lost 5 Stone in just 8 months
“I would advise anyone considering this programme that it's a transformative experience. It has allowed me to embrace life and fully enjoy my twenties.”
Susan lost 5 Stone in just 12 months
“For the first time, losing weight has been both easy and successful in my life.”
Cadi lost 3 Stone in just 12 months
“If you're aiming to lose weight or manage polycystic ovaries, go for this program. It's undoubtedly the best decision.”
Ethan lost 5 Stone in just 5 months
“I’ve never felt so comfortable in my own skin. It's a newfound sense of confidence and well-being that has positively impacted every aspect of my life.”
Dimitra lost 4 Stone in just 8 months
“I cannot recommend this programme enough; it truly works! It's the sole solution that has been effective after my long struggle.”
Lauren lost 5 Stone in just 8 months
“I would advise anyone considering this programme that it's a transformative experience. It has allowed me to embrace life and fully enjoy my twenties.”
